This webpage is intended for UK patients who have been prescribed Metoject® PEN (methotrexate). If you are not, please click here.

The first injection of subcutaneous methotrexate PEN should be performed under direct medical supervision. However, your doctor may decide that you can learn how to inject subcutaneous methotrexate PEN yourself. You will receive appropriate training for you to do this. Metoject® PEN is injected once weekly.

Metoject® PEN (methotrexate) For Dermatology

Metoject® PEN is used to treat moderate to severe psoriasis in adult patients who are candidates for systemic therapy, and severe psoriatic arthritis in adults1. 

Metoject (methotrexate) is contraindicated in the case of pregnancy and breastfeeding 

Methotrexate in Dermatology

Known as a systemic treatment, methotrexate acts on the whole body rather than targeting one area2. 

Methotrexate has been used to treat psoriasis for many years3, and it works by calming down the body’s immune system, preventing it from attacking itself. This in turn helps to reduce the thickened skin in psoriasis4. Like any medicine, methotrexate can cause side effects. Please refer to Patient Safety for more information.  

 

Reporting of Side Effects

If you get any side effects, talk to your healthcare professional. This includes any possible side effects not listed in the Patient Information Leaflet contained within your subcutaneous methotrexate PEN carton.   

You can also report side effects directly via the Yellow Card Scheme at yellowcard.mhra.gov.uk.   

By reporting side effects, you can help provide more information on the safety of this medicine. 

Further Information & Questions

Visit our contact page to submit an enquiry   

References:

  1. Metoject® Summary of Product Characteristics. [online] Available at: https://www.medicines.org.uk/emc/search?q=metoject#gref/. Last Accessed July 2025
  2. Systemic Treatments. Psoriasis Association. [online] Available at: psoriasis-association.org.uk/systemics. Last Accessed July 2025.
  3. Psoriasis Association. [online] Available at: www.psoriasis-association.org.uk/methotrexate. Last Accessed July 2025.
  4. Common Questions about Methotrexate. NHS.uk. [online] Available at: www.nhs.uk/medicines/methotrexate/common-questions-about-methotrexate/. Last Accessed July 2025.

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