This webpage is intended for UK patients who have been prescribed Metoject® PEN. If you are not, please click here.

Introducing the NEW button-free Metoject® PEN

Offering the simplicity of a button-free autoinjector, purpose designed with patient-friendly features – Available from March 2024

Metoject® PEN For Rheumatology

Metoject® PEN is used to treat active rheumatoid arthritis in adult patients, polyarthritic forms of severe, active juvenile idiopathic arthritis (JIA) and psoriatic arthritis4

Methotrexate in Rheumatology

Methotrexate is the most commonly prescribed drug for the treatment of rheumatoid arthritis and will often be the first drug to be prescribed5.

The National Rheumatoid Arthritis Society (NRAS) describes methotrexate as the ‘gold standard’ disease modifying anti-rheumatic drug (DMARD) for the control of inflammatory arthritis5.

Methotrexate works by calming down the body’s immune system, preventing it from attacking itself. This reduces the swelling and inflammation that causes swollen and stiff joints2.

Methotrexate for Rheumatoid Arthritis Patient Support Videos

Understanding methotrexate – this video tells you all you need to know about how Methotrexate works, its benefits and possible side-effects.

In this introduction video we are joined by Tracy French, Rheumatology Clinical Nurse Specialist at University Hospitals Bristol. Tracy runs through the ‘ASK’ approach and how to approach your RA journey.

Your Consultation7

Your consultation is an important point in your treatment journey,  it is key in finding the best treatment for you. It can feel overwhelming, but remembering the ASK approach will help you to make the most of this time with your healthcare professional for positive treatment outcomes.

Address your main concerns at the start of your consultation.

Recent survey findings have shown that only 45% of patients had been able to voice their concerns about their treatment options. It is important to speak up and address any thoughts or concerns you may have, because if you don’t tell your healthcare professional, they won’t know what your personal needs or preferences are. The more information they know the better, and this can be used to make a decision with you, rather than for you.

Share details of your symptoms, prioritising those that have the most impact on your quality of life.

Symptoms can have a major impact on your quality of life. With 66% of patients struggling with their mental health, sharing details of your symptoms with your healthcare team will help them to understand you needs, and might help to shape their treatment recommendation. It is advised that you prepare for your consultation by noting down answers to questions that your healthcare professional might ask every time they see you. By having the answers ready, this leaves more time to discuss your concerns and priorities, which you can also write down in a list.

Know everything about your prescribed treatment.

Only 35% of patients surveyed left their first consultation feeling as though they’d received enough information about the proposed treatment from their consultant. Importantly, people who had lots of information responded better to their first treatment. It is important that you know as much as possible about your proposed treatment, including benefits, possible side effects and the time it takes to work.

It is encouraged that you contact your healthcare team early if you are experiencing any issues, as there are different things that they can suggest to help. As medications are intended to use long term, it’s important to address issues promptly and find the therapy that suits you, rather than persevering with feeling unwell or simply stopping the medication.

The more you know about your options before you start the treatment, the better prepared you will be to manage any problems that may occur.

The ASK Approach will enable you to make the best decision possible about your treatment.

Please visit the National Rheumatoid Arthritis Society’s webpage at for more rheumatoid arthritis specific information and support

Metoject® PEN should only be administered once per week

Support materials

Further information on how to use or administer Metoject® PEN for adults and juveniles visit the support materials page.

Reporting Side Effects

If you get any side effects, talk to your healthcare professional. This includes any possible side effects not listed in the Patient Information Leaflet contained within your Metoject® PEN carton.

You can also report side effects directly via the Yellow Card Scheme at

By reporting side effects, you can help provide more information on the safety of this medicine.

Further Information & Questions


  1. About Methotrexate. [online] Available at: Last Accessed May 2023.
  2. Common Questions about Methotrexate. [online] Available at: Last Accessed May 2023.
  3. Psoriasis Association. [online] Available at: Last Accessed May 2023.
  4. Metoject® Summary of Product Characteristics. [online] Available at: Last Accessed May 2023
  5. Methotrexate and Its Use in Rheumatoid Arthritis (RA). NRAS. [online] Available at: Last Accessed May 2023.
  6. Systemic Treatments. Psoriasis Association. [online] Available at: Last Accessed May 2023.
  7. How to Approach Your Rheumatology Consultation. [online] Available at: Last Accessed June 2023.